ABSTRACT
The cerebellum is a key structure involved in coordinated motor planning, cognition, learning and memory functions. This study presents a permanent model of a toxin produced cerebellar lesion characterized according to contemporary motor and cognitive abnormalities. In this experimental study, slow administration of quinolinic acid [QA, 5 microl of 200 micromol, 1 microl/minute] in the right cerebellar hemisphere [lobule VI] caused noticeable motor and cognitive disturbances along with cellular degeneration in all treated animals. We assessed behavioral and histopathological studies over ten weeks after QA treatment. The data were analyzed with ANOVA and the student's t test. The QA treated group showed marked motor learning deficits on the rotating rod test [p